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The compatibility of cyclosporine and methylprednisolone at simulated Y-site administration was studied by this research. Each cyclosporine (CP) to methylprednisolone (MP) was diluted in the concentration 0.5 ㎎/㎖ and 1.25 ㎎/㎖ respectively. As diluent, 5% dextrose water (D5W) or normal saline (NS) was used. Each the above diluted solution was mixed in the 1:1 ratio by the following compositions : a) CP/D5W + MP/D5W ; b) CP/D5W + MP/NS ; c) CP/NS + MP/D5W ; 4) CP/NS + MP/NS. After that, each mixture solution a), b), c), and d) was checked for precipitation, pH and the concentrations at 0, 0.5, 1.0, 2.0, 3.0, 4.0 hrs after mixing by the HPLC method. As the result, all of the above mixture solutions had no precipitation, and no significant pH differences (7.04∼7.30). Also, over the 4 hour study periods, the content of each cyclosporine or methylprednisolone was more than 90% at all the time. This study has been showed the diluted cyclosporine and methylprednisolone was compatible at Y-site administration, and it can be possible to apply for the further patient care.
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